Lens Landmarks
In The Lens Landmarks, we summarize landmark studies in ophthalmology. We will continue to add to the list weekly. Check out the links below (or scroll down the page to search for landmark studies by subspecialty.
Studies & Trials by Subspecialty
Cornea
- Herpetic Eye Disease Studies (HEDS) - Part I
- Herpetic Eye Disease Studies (HEDS) - Part II
- Collaborative Corneal Transplantation Studies (CCTS)
- Cornea Donor Study (CDS)
- Cornea Preservation Time Study (CPTS)
- Steroids for Corneal Ulcers Trial (SCUT)
- Mycotic Ulcer Treatment Trial 1 (MUTT 1)
- Mycotic Ulcer Treatment Trial 2 (MUTT 2)
- Collaborative Longitudinal Evaluation of Keratoconus Study (CLEK)
- Descemet Endothelial Thickness Comparison Trial (DETECT)
Neuro-ophthalmology
- Optic Neuritis Treatment Trial (ONTT)
- Ischemic Optic Neuropathy Decompression Trial (IONDT)
- Clinically Significant Head Injury (CRASH)
- Idiopathic Intracranial Hypertension Treatment Trial (IIHTT)
Glaucoma
- Baltimore Eye Study
- Advanced Glaucoma Intervention Study (AGIS)
- Glaucoma Laser Trial (GLT)
- Collaborative Normal Tension Glaucoma Study (CNTGS)
- Collaborative Initial Glaucoma Treatment Study (CIGTS)
- Ocular Hypertension Treatment Study (OHTS)
- Early Manifest Glaucoma Trial (EMGT)
- Ahmed Baerveldt Comparison Study (ABC)
- Ahmed versus Baerveldt (AVB)
- Tube versus Trabeculectomy (TVT)
- United Kingdom Glaucoma Treatment Study (UKGTS)
- HORIZON (Hydrus Microstent)
Pediatrics
- Cryotherapy for ROP (CRYO-ROP)
- Supplemental Therapeutic Oxygen for Prethreshold ROP (STOP-ROP)
- Early Treatment for ROP (ET-ROP)
- Bevacizumab for ROP (BEAT-ROP)
- ATS - Atropine vs. Patch
- ATS - Patching vs. Correction
- Atropine in the Treatment of Myopia I (ATOM I)
- Atropine in the Treatment of Myopia II (ATOM II)
- Low-Concentration Atropine for Myopia Progression (LAMP)
- Infant Aphakia Treatment Study (IATS)
Retina (Diabetic Retinopathy)
- Diabetic Retinopathy Study (DRS)
- Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR)
- Diabetic Retinopathy Vitrectomy Study (DRVS)
- Early Treatment Diabetic Retinopathy Study (ETDRS)
- Diabetes Control and Complications Trial (DCCT)
- United Kingdom Prospective Diabetes Study (UKPDS)
- DRCR Protocol I
- DRCR Protocol T
- DRCR Protocol S
- DRCR Protocol V
Retina (AMD)
- Prevalence of Age-Related Maculopathy: The Beaver Dam Eye Study
- Treatment of AMD with Phototherapy (TAP)
- Age Related Eye Disease Study 1 (AREDS1)
- Age Related Eye Disease Study 2 (AREDS2)
- MARINA (Ranibizumab vs. Sham)
- ANCHOR (Ranibizumab vs. PDT)
- PIER & EXCITE (Ranibizumab Extension)
- VIEW1 & VIEW2 (Aflibercept)
- Comparison of AMD Treatments Trials (CATT)
- Tolerating Subretinal Fluid (FLUID)
Retina (Other)
- Endophthalmitis Vitrectomy Study (EVS)
- Branch Vein Occlusion Study (BVOS)
- Central Vein Occlusion Study (CVOS)
- Risk Factors for Branch and Central Retinal Vein Occlusion
- SCORE-CRVO (Corticosteroid for Retinal Vein Occlusion)
- BRAVO & CRUISE (Ranibizumab for Macular Edema)
- Luxturna Gene Therapy Phase III Trial
- PIVOT (Pneumatic Retinopexy vs. Vitrectomy)
Plastics, Oncology, Uveitis
- Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy
- Systemic Immunosuppressive Therapy for Eye Diseases (SITE)
- Collaborative Ocular Melanoma Study (COMS)
- Standardization of Uveitis Nomenclature (SUN)
- Multicenter Uveitis Steroid Treatment Trial (MUST)
- PeriOcular versus INTravitreal corticosteroids for uveitic macular edema (POINT) Trial
Please reach out to TheLens@lensophthalmology.com if you think there is a trial/study that should be added to the list!
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