The SCUT trial (2012)
Can you count on corticosteroids to do the scutwork in bacterial keratitis? In the 2012 SCUT study, patients with known bacterial corneal ulcers were randomized to treatment with prednisolone (n = 250) and placebo (n = 250) 48 hours after receiving Vigamox.
Overall, the SCUT study is a landmark study because it showed that topical corticosteroids were not dangerous in the treatment of bacterial corneal ulcers and actually led to improved outcomes in a subset of patients with more severe presentations.
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